SUN/KASH interactions facilitate force transmission across the nuclear envelope.

LINC complexes (Linker of Nucleoskeleton and Cytoskeleton), consisting of inner nuclear membrane SUN (Sad1, UNC-84) proteins and outer nuclear membrane KASH (Klarsicht, ANC-1, and Syne Homology) proteins, are essential for nuclear positioning, cell migration and chromosome dynamics. To test the in vivo functions of conserved interfaces revealed by crystal structures, Cain et al used a combination of Caenorhabditis elegans genetics, imaging in cultured NIH 3T3 fibroblasts, and Molecular Dynamic simulations, to study SUN-KASH interactions. Conserved aromatic residues at the -7 position of the C-termini of KASH proteins and conserved disulfide bonds in LINC complexes play important roles in force transmission across the nuclear envelope. Other properties of LINC complexes, such as the helices preceding the SUN domain, the longer coiled-coils spanning the perinuclear space and higher-order organization may also function to transmit mechanical forces generated by the cytoskeleton across the nuclear envelope

Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis.

Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic development. Defective neural crest development can cause severe and common structural birth defects, such as craniofacial anomalies and congenital heart disease. In the early vertebrate embryos, NC cells emerge from the dorsal edge of the neural tube during neurulation and then migrate extensively throughout the anterior-posterior body axis to generate numerous derivatives. Wnt signaling plays essential roles in embryonic development and cancer. This review summarizes current understanding of Wnt signaling in NC cell induction, delamination, migration, multipotency, and fate determination, as well as in NC-derived cancers

Strong Optical and UV Intermediate-Width Emission Lines in the Quasar SDSS J232444.80-094600.3: Dust-Free and Intermediate-Density Gas at the Skin of Dusty Torus ?

Emission lines from the broad emission line region (BELR) and the narrow emission line region (NELR) of active galactic nuclei (AGNs) are extensively studied. However, between these two regions emission lines are rarely detected. We present a detailed analysis of a quasar SDSS J232444.80-094600.3 (SDSS J2324$-$0946), which is remarkable for its strong intermediate-width emission lines (IELs) with FWHM $\approx$ 1800 \kmps. The IEL component is presented in different emission lines, including the permitted lines \lya\ $\lambda$1216, \civ\ $\lambda$1549, semiforbidden line \ciii\ $\lambda$1909, and forbidden lines \oiii\ $\lambda\lambda$4959, 5007. With the aid of photo-ionization models, we found that the IELs are produced by gas with a hydrogen density of $n_{\rm H} \sim 10^{6.2}-10^{6.3}~\rm cm^{-3}$, a distance to the central ionizing source of $R \sim 35-50$ pc, a covering factor of CF $\sim$ 6\%, and a dust-to-gas ratio of $\leq 4\%$ times of SMC. We suggest that the strong IELs of this quasar are produced by nearly dust-free and intermediate-density gas located at the skin of the dusty torus. Such strong IELs, served as a useful diagnose, can provide an avenue to study the properties of gas between the BELR and the NELR

Research on 4-dimensional Systems without Equilibria with Application

Recently chaos-based encryption has been obtained more and more attention. Chaotic systems without equilibria may be suitable to be used to design pseudorandom number generators (PRNGs) because there does not exist corresponding chaos criterion theorem on such systems. This paper proposes two propositions on 4-dimensional systems without equilibria. Using one of the propositions introduces a chaotic system without equilibria. Using this system and the generalized chaos synchronization (GCS) theorem constructs an 8-dimensional discrete generalized chaos synchronization (8DBDGCS) system. Using the 8DBDGCS system designs a 216-word chaotic PRNG. Simulation results show that there are no significant correlations between the key stream and the perturbed key streams generated via the 216-word chaotic PRNG. The key space of the chaotic PRNG is larger than 21275. As an application, the chaotic PRNG is used with an avalanche-encryption scheme to encrypt an RGB image. The results demonstrate that the chaotic PRNG is able to generate the avalanche effects which are similar to those generated via ideal chaotic PRNGs

Anti-Washout Concrete: An overview

Anti-washout concrete (AWC) is a special cement-based material that can be directly employed in underwater environments without dispersion. It was developed around 50 years ago, and more than 150 journal articles and technical reports have been published. This paper provides a holistic review about the basic fresh-state and hardened-state properties of the AWC, such as water (washout) resistance, consistency, bleeding and segregation resistance, mechanical properties, and durability, as well as relevant testing methods. The discrepancies between AWC\u27s characteristics and those of conventional concrete are clearly presented. The mixture compositions, supplementary cementitious materials (SCMs), and other conditions that affect AWC\u27s performance are also elaborated. Finally, the paper discusses the specific performance requirements of AWC and corresponding construction strategies for its different applications, including normal construction, marine engineering, bulk filling, and repair practices. Future research needs to stimulate the development of AWC are also discussed

Design of Magnesium Phosphate Cement Based Composite for High Performance Bipolar Plate of Fuel Cells

In this work, we report a comprehensive study on a magnesium phosphate cement (MPC) based composite as the construction material for high performance bipolar plates of fuel cells. MPC with partial replacement of fly ash was employed as the binding matrix. Some carbon-based materials, such as graphite, carbon black, carbon fiber, and multi-walled carbon nanotubes were used to construct the conductive phase. A simple hot-press process was applied to produce the composite. The formula and the structure of the composite was modified and adjusted to optimize the properties of the composite to meet the US DOE 2015 technical targets, including the introducing of a reinforcement support. Finally, all the technical targets such as electrical conductivity (\u3e100 S cm-1), the flexural strength (\u3e25 MPa), the corrosion resistance ( \u3c 1 μA cm-2), and gas permeability ( \u3c 10-5 cm3 (s cm2)-1) were achieved as well as low cost ( \u3c 5 $ per kW). The optimized formula and the detailed procedures to fabricate the MPC based composite were concluded